ChloroquineV1, France, Analysis, bibRecord, 000025

Unmet need in rheumatology: reports from the Targeted Therapies meeting 2019

Identifieur interne : 000025 ( France/Analysis ); précédent : 000024; suivant : 000026

Unmet need in rheumatology: reports from the Targeted Therapies meeting 2019

Auteurs : Kevin L. Winthrop [États-Unis] ; Michael E. Weinblatt [États-Unis] ; Joan Bathon [États-Unis] ; Gerd R. Burmester [Allemagne] ; Philip J. Mease [États-Unis] ; Leslie Crofford [États-Unis] ; Vivian Bykerk [États-Unis] ; Maxime Dougados [France] ; James Todd Rosenbaum [États-Unis] ; Xavier Mariette [France] ; Joachim Sieper [Allemagne] ; Fritz Melchers [Allemagne] ; Bruce N. Cronstein [États-Unis] ; Ferry C. Breedveld [Pays-Bas] ; Joachim Kalden [Allemagne] ; Josef S. Smolen [Autriche] ; Daniel Furst [États-Unis, Italie]

Source :

Annals of the Rheumatic Diseases [ 0003-4967 ] ; 2019.

RBID : PMC:6937409

Abstract

Objectives

To detail the greatest areas of unmet scientific and clinical needs in rheumatology.

Methods

The 21st annual international Advances in Targeted Therapies meeting brought together more than 100 leading basic scientists and clinical researchers in rheumatology, immunology, epidemiology, molecular biology and other specialties. During the meeting, breakout sessions were convened, consisting of 5 disease-specific groups with 20–30 experts assigned to each group based on expertise. Specific groups included: rheumatoid arthritis, psoriatic arthritis, axial spondyloarthritis, systemic lupus erythematosus and other systemic autoimmune rheumatic diseases. In each group, experts were asked to identify unmet clinical and translational research needs in general and then to prioritise and detail the most important specific needs within each disease area.

Results

Overarching themes across all disease states included the need to innovate clinical trial design with emphasis on studying patients with refractory disease, the development of trials that take into account disease endotypes and patients with overlapping inflammatory diseases, the need to better understand the prevalence and incidence of inflammatory diseases in developing regions of the world and ultimately to develop therapies that can cure inflammatory autoimmune diseases.

Conclusions

Unmet needs for new therapies and trial designs, particularly for those with treatment refractory disease, remain a top priority in rheumatology.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6937409

DOI: 10.1136/annrheumdis-2019-216151
PubMed: 31662322
PubMed Central: 6937409

Affiliations:

Allemagne, Autriche, France, Italie, Pays-Bas, États-Unis

Links to Exploration step

PMC:6937409

Le document en format XML

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</nlm:aff>
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<author><name sortKey="Smolen, Josef S" sort="Smolen, Josef S" uniqKey="Smolen J" first="Josef S" last="Smolen">Josef S. Smolen</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Unmet need in rheumatology: reports from the Targeted Therapies meeting 2019</title>
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<author><name sortKey="Weinblatt, Michael E" sort="Weinblatt, Michael E" uniqKey="Weinblatt M" first="Michael E" last="Weinblatt">Michael E. Weinblatt</name>
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<author><name sortKey="Bathon, Joan" sort="Bathon, Joan" uniqKey="Bathon J" first="Joan" last="Bathon">Joan Bathon</name>
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<author><name sortKey="Burmester, Gerd R" sort="Burmester, Gerd R" uniqKey="Burmester G" first="Gerd R" last="Burmester">Gerd R. Burmester</name>
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<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<author><name sortKey="Mease, Philip J" sort="Mease, Philip J" uniqKey="Mease P" first="Philip J" last="Mease">Philip J. Mease</name>
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<author><name sortKey="Crofford, Leslie" sort="Crofford, Leslie" uniqKey="Crofford L" first="Leslie" last="Crofford">Leslie Crofford</name>
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<author><name sortKey="Bykerk, Vivian" sort="Bykerk, Vivian" uniqKey="Bykerk V" first="Vivian" last="Bykerk">Vivian Bykerk</name>
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<author><name sortKey="Dougados, Maxime" sort="Dougados, Maxime" uniqKey="Dougados M" first="Maxime" last="Dougados">Maxime Dougados</name>
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<author><name sortKey="Rosenbaum, James Todd" sort="Rosenbaum, James Todd" uniqKey="Rosenbaum J" first="James Todd" last="Rosenbaum">James Todd Rosenbaum</name>
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,<addr-line content-type="state">Oregon</addr-line>
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</nlm:aff>
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<author><name sortKey="Mariette, Xavier" sort="Mariette, Xavier" uniqKey="Mariette X" first="Xavier" last="Mariette">Xavier Mariette</name>
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,<addr-line content-type="city">Le Kremlin Bicêtre</addr-line>
,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<author><name sortKey="Sieper, Joachim" sort="Sieper, Joachim" uniqKey="Sieper J" first="Joachim" last="Sieper">Joachim Sieper</name>
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,<institution>Infectious Diseases and Rheumatology, Campus Benjamin Franklin, Charité</institution>
,<addr-line content-type="city">Berlin</addr-line>
,<country>Germany</country>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<author><name sortKey="Melchers, Fritz" sort="Melchers, Fritz" uniqKey="Melchers F" first="Fritz" last="Melchers">Fritz Melchers</name>
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,<addr-line content-type="city">Berlin</addr-line>
,<country>Germany</country>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Cronstein, Bruce N" sort="Cronstein, Bruce N" uniqKey="Cronstein B" first="Bruce N" last="Cronstein">Bruce N. Cronstein</name>
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,<addr-line content-type="city">New York City</addr-line>
,<addr-line content-type="state">New York</addr-line>
,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Breedveld, Ferry C" sort="Breedveld, Ferry C" uniqKey="Breedveld F" first="Ferry C" last="Breedveld">Ferry C. Breedveld</name>
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,<addr-line content-type="city">Leiden</addr-line>
,<country>The Netherlands</country>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kalden, Joachim" sort="Kalden, Joachim" uniqKey="Kalden J" first="Joachim" last="Kalden">Joachim Kalden</name>
<affiliation wicri:level="1"><nlm:aff id="aff15"><institution>University of Erlangen</institution>
,<addr-line content-type="city">Erlangen</addr-line>
,<country>Germany</country>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Smolen, Josef S" sort="Smolen, Josef S" uniqKey="Smolen J" first="Josef S" last="Smolen">Josef S. Smolen</name>
<affiliation wicri:level="1"><nlm:aff id="aff16"><institution>Division of Rheumatology, Department of Medicine 3, Medical University of, Vienna</institution>
,<addr-line content-type="city">Vienna</addr-line>
,<country>Austria</country>
</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Furst, Daniel" sort="Furst, Daniel" uniqKey="Furst D" first="Daniel" last="Furst">Daniel Furst</name>
<affiliation wicri:level="1"><nlm:aff id="aff5"><institution>Swedish Medical Center, University of Washington</institution>
,<addr-line content-type="city">Seattle</addr-line>
,<addr-line content-type="state">Washington</addr-line>
,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff17"><institution>University of California, Los Angeles Medical Center</institution>
,<addr-line content-type="city">Los Angeles</addr-line>
,<addr-line content-type="state">CA</addr-line>
,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff18"><institution>University of Florence</institution>
,<addr-line content-type="city">Florence</addr-line>
,<country>Italy</country>
</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
</analytic>
<series><title level="j">Annals of the Rheumatic Diseases</title>
<idno type="ISSN">0003-4967</idno>
<idno type="eISSN">1468-2060</idno>
<imprint><date when="2019">2019</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><sec><title>Objectives</title>
<p>To detail the greatest areas of unmet scientific and clinical needs in rheumatology.</p>
</sec>
<sec><title>Methods</title>
<p>The 21st annual international Advances in Targeted Therapies meeting brought together more than 100 leading basic scientists and clinical researchers in rheumatology, immunology, epidemiology, molecular biology and other specialties. During the meeting, breakout sessions were convened, consisting of 5 disease-specific groups with 20–30 experts assigned to each group based on expertise. Specific groups included: rheumatoid arthritis, psoriatic arthritis, axial spondyloarthritis, systemic lupus erythematosus and other systemic autoimmune rheumatic diseases. In each group, experts were asked to identify unmet clinical and translational research needs in general and then to prioritise and detail the most important specific needs within each disease area.</p>
</sec>
<sec><title>Results</title>
<p>Overarching themes across all disease states included the need to innovate clinical trial design with emphasis on studying patients with refractory disease, the development of trials that take into account disease endotypes and patients with overlapping inflammatory diseases, the need to better understand the prevalence and incidence of inflammatory diseases in developing regions of the world and ultimately to develop therapies that can cure inflammatory autoimmune diseases.</p>
</sec>
<sec><title>Conclusions</title>
<p>Unmet needs for new therapies and trial designs, particularly for those with treatment refractory disease, remain a top priority in rheumatology.</p>
</sec>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Furst, De" uniqKey="Furst D">DE Furst</name>
</author>
<author><name sortKey="Keystone, Ec" uniqKey="Keystone E">EC Keystone</name>
</author>
<author><name sortKey="So, Ak" uniqKey="So A">AK So</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Singh, Ja" uniqKey="Singh J">JA Singh</name>
</author>
<author><name sortKey="Saag, Kg" uniqKey="Saag K">KG Saag</name>
</author>
<author><name sortKey="Bridges, Sl" uniqKey="Bridges S">SL Bridges</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Smolen, Js" uniqKey="Smolen J">JS Smolen</name>
</author>
<author><name sortKey="Landewe, R" uniqKey="Landewe R">R Landewé</name>
</author>
<author><name sortKey="Bijlsma, J" uniqKey="Bijlsma J">J Bijlsma</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gossec, L" uniqKey="Gossec L">L Gossec</name>
</author>
<author><name sortKey="Smolen, Js" uniqKey="Smolen J">JS Smolen</name>
</author>
<author><name sortKey="Ramiro, S" uniqKey="Ramiro S">S Ramiro</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Winthrop, Kl" uniqKey="Winthrop K">KL Winthrop</name>
</author>
<author><name sortKey="Strand, V" uniqKey="Strand V">V Strand</name>
</author>
<author><name sortKey="Van Der Heijde, Dm" uniqKey="Van Der Heijde D">DM van der Heijde</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zhang, F" uniqKey="Zhang F">F Zhang</name>
</author>
<author><name sortKey="Wei, K" uniqKey="Wei K">K Wei</name>
</author>
<author><name sortKey="Slowikowski, K" uniqKey="Slowikowski K">K Slowikowski</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Emery, P" uniqKey="Emery P">P Emery</name>
</author>
<author><name sortKey="Breedveld, Fc" uniqKey="Breedveld F">FC Breedveld</name>
</author>
<author><name sortKey="Hall, S" uniqKey="Hall S">S Hall</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Becede, M" uniqKey="Becede M">M Becede</name>
</author>
<author><name sortKey="Alasti, F" uniqKey="Alasti F">F Alasti</name>
</author>
<author><name sortKey="Gessl, I" uniqKey="Gessl I">I Gessl</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Heijde, D" uniqKey="Heijde D">D Heijde</name>
</author>
<author><name sortKey="Strand, V" uniqKey="Strand V">V Strand</name>
</author>
<author><name sortKey="Tanaka, Y" uniqKey="Tanaka Y">Y Tanaka</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mease, Pj" uniqKey="Mease P">PJ Mease</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mease, Pj" uniqKey="Mease P">PJ Mease</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Baraliakos, X" uniqKey="Baraliakos X">X Baraliakos</name>
</author>
<author><name sortKey="Coates, Lc" uniqKey="Coates L">LC Coates</name>
</author>
<author><name sortKey="Braun, J" uniqKey="Braun J">J Braun</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mease, P" uniqKey="Mease P">P Mease</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Weinblatt, M" uniqKey="Weinblatt M">M Weinblatt</name>
</author>
<author><name sortKey="Schiff, M" uniqKey="Schiff M">M Schiff</name>
</author>
<author><name sortKey="Goldman, A" uniqKey="Goldman A">A Goldman</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Brikman, S" uniqKey="Brikman S">S Brikman</name>
</author>
<author><name sortKey="Furer, V" uniqKey="Furer V">V Furer</name>
</author>
<author><name sortKey="Wollman, J" uniqKey="Wollman J">J Wollman</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="H Jgaard, P" uniqKey="H Jgaard P">P Højgaard</name>
</author>
<author><name sortKey="Ellegaard, K" uniqKey="Ellegaard K">K Ellegaard</name>
</author>
<author><name sortKey="Nielsen, Sm" uniqKey="Nielsen S">SM Nielsen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Fibromyalgia, Mpj" uniqKey="Fibromyalgia M">MPJ Fibromyalgia</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Molt, A" uniqKey="Molt A">A Moltó</name>
</author>
<author><name sortKey="Etcheto, A" uniqKey="Etcheto A">A Etcheto</name>
</author>
<author><name sortKey="Gossec, L" uniqKey="Gossec L">L Gossec</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Smolen, Js" uniqKey="Smolen J">JS Smolen</name>
</author>
<author><name sortKey="Schols, M" uniqKey="Schols M">M Schöls</name>
</author>
<author><name sortKey="Braun, J" uniqKey="Braun J">J Braun</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Aletaha, D" uniqKey="Aletaha D">D Aletaha</name>
</author>
<author><name sortKey="Neogi, T" uniqKey="Neogi T">T Neogi</name>
</author>
<author><name sortKey="Silman, Aj" uniqKey="Silman A">AJ Silman</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Winthrop, Kl" uniqKey="Winthrop K">KL Winthrop</name>
</author>
<author><name sortKey="Weinblatt, Me" uniqKey="Weinblatt M">ME Weinblatt</name>
</author>
<author><name sortKey="Crow, Mk" uniqKey="Crow M">MK Crow</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Rosenbaum, Jt" uniqKey="Rosenbaum J">JT Rosenbaum</name>
</author>
<author><name sortKey="Asquith, M" uniqKey="Asquith M">M Asquith</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Choi, Ry" uniqKey="Choi R">RY Choi</name>
</author>
<author><name sortKey="Asquith, M" uniqKey="Asquith M">M Asquith</name>
</author>
<author><name sortKey="Rosenbaum, Jt" uniqKey="Rosenbaum J">JT Rosenbaum</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Baeten, D" uniqKey="Baeten D">D Baeten</name>
</author>
<author><name sortKey=" Stergaard, M" uniqKey=" Stergaard M">M Østergaard</name>
</author>
<author><name sortKey="Wei, Jc C" uniqKey="Wei J">JC-C Wei</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Siebert, S" uniqKey="Siebert S">S Siebert</name>
</author>
<author><name sortKey="Millar, Nl" uniqKey="Millar N">NL Millar</name>
</author>
<author><name sortKey="Mcinnes, Ib" uniqKey="Mcinnes I">IB McInnes</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ciccia, F" uniqKey="Ciccia F">F Ciccia</name>
</author>
<author><name sortKey="Guggino, G" uniqKey="Guggino G">G Guggino</name>
</author>
<author><name sortKey="Rizzo, A" uniqKey="Rizzo A">A Rizzo</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gravallese, Em" uniqKey="Gravallese E">EM Gravallese</name>
</author>
<author><name sortKey="Schett, G" uniqKey="Schett G">G Schett</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Seo, Mr" uniqKey="Seo M">MR Seo</name>
</author>
<author><name sortKey="Baek, Hl" uniqKey="Baek H">HL Baek</name>
</author>
<author><name sortKey="Yoon, Hh" uniqKey="Yoon H">HH Yoon</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Rosenbaum, Jt" uniqKey="Rosenbaum J">JT Rosenbaum</name>
</author>
<author><name sortKey="Pisenti, L" uniqKey="Pisenti L">L Pisenti</name>
</author>
<author><name sortKey="Park, Y" uniqKey="Park Y">Y Park</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Braun, J" uniqKey="Braun J">J Braun</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Erbil, J" uniqKey="Erbil J">J Erbil</name>
</author>
<author><name sortKey="Espinoza, Lr" uniqKey="Espinoza L">LR Espinoza</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Clowse, Meb" uniqKey="Clowse M">MEB Clowse</name>
</author>
<author><name sortKey="Wallace, Dj" uniqKey="Wallace D">DJ Wallace</name>
</author>
<author><name sortKey="Furie, Ra" uniqKey="Furie R">RA Furie</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Merrill, Jt" uniqKey="Merrill J">JT Merrill</name>
</author>
<author><name sortKey="Van Vollenhoven, Rf" uniqKey="Van Vollenhoven R">RF van Vollenhoven</name>
</author>
<author><name sortKey="Buyon, Jp" uniqKey="Buyon J">JP Buyon</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kalunian, Kc" uniqKey="Kalunian K">KC Kalunian</name>
</author>
<author><name sortKey="Merrill, Jt" uniqKey="Merrill J">JT Merrill</name>
</author>
<author><name sortKey="Maciuca, R" uniqKey="Maciuca R">R Maciuca</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Merrill, Jt" uniqKey="Merrill J">JT Merrill</name>
</author>
<author><name sortKey="Shanahan, Wr" uniqKey="Shanahan W">WR Shanahan</name>
</author>
<author><name sortKey="Scheinberg, M" uniqKey="Scheinberg M">M Scheinberg</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hruskova, Z" uniqKey="Hruskova Z">Z Hruskova</name>
</author>
<author><name sortKey="Tesar, V" uniqKey="Tesar V">V Tesar</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mahieu, Ma" uniqKey="Mahieu M">MA Mahieu</name>
</author>
<author><name sortKey="Strand, V" uniqKey="Strand V">V Strand</name>
</author>
<author><name sortKey="Simon, Ls" uniqKey="Simon L">LS Simon</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Abrahamowicz, M" uniqKey="Abrahamowicz M">M Abrahamowicz</name>
</author>
<author><name sortKey="Esdaile, Jm" uniqKey="Esdaile J">JM Esdaile</name>
</author>
<author><name sortKey="Ramsey Goldman, R" uniqKey="Ramsey Goldman R">R Ramsey-Goldman</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tarazi, M" uniqKey="Tarazi M">M Tarazi</name>
</author>
<author><name sortKey="Gaffney, Rg" uniqKey="Gaffney R">RG Gaffney</name>
</author>
<author><name sortKey="Feng, R" uniqKey="Feng R">R Feng</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Oon, S" uniqKey="Oon S">S Oon</name>
</author>
<author><name sortKey="Huq, M" uniqKey="Huq M">M Huq</name>
</author>
<author><name sortKey="Golder, V" uniqKey="Golder V">V Golder</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Morand, Ef" uniqKey="Morand E">EF Morand</name>
</author>
<author><name sortKey="Trasieva, T" uniqKey="Trasieva T">T Trasieva</name>
</author>
<author><name sortKey="Berglind, A" uniqKey="Berglind A">A Berglind</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Pisetsky, Ds" uniqKey="Pisetsky D">DS Pisetsky</name>
</author>
<author><name sortKey="Spencer, Dm" uniqKey="Spencer D">DM Spencer</name>
</author>
<author><name sortKey="Lipsky, Pe" uniqKey="Lipsky P">PE Lipsky</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Dall Era, M" uniqKey="Dall Era M">M Dall'Era</name>
</author>
<author><name sortKey="Bruce, In" uniqKey="Bruce I">IN Bruce</name>
</author>
<author><name sortKey="Gordon, C" uniqKey="Gordon C">C Gordon</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tonner, C" uniqKey="Tonner C">C Tonner</name>
</author>
<author><name sortKey="Schmajuk, G" uniqKey="Schmajuk G">G Schmajuk</name>
</author>
<author><name sortKey="Yazdany, J" uniqKey="Yazdany J">J Yazdany</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Yazdany, J" uniqKey="Yazdany J">J Yazdany</name>
</author>
<author><name sortKey="Robbins, M" uniqKey="Robbins M">M Robbins</name>
</author>
<author><name sortKey="Schmajuk, G" uniqKey="Schmajuk G">G Schmajuk</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Narvaez, J" uniqKey="Narvaez J">J Narváez</name>
</author>
<author><name sortKey="Borrell, H" uniqKey="Borrell H">H Borrell</name>
</author>
<author><name sortKey="Sanchez Alonso, F" uniqKey="Sanchez Alonso F">F Sánchez-Alonso</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kearsley Fleet, L" uniqKey="Kearsley Fleet L">L Kearsley-Fleet</name>
</author>
<author><name sortKey="Zavada, J" uniqKey="Zavada J">J Zavada</name>
</author>
<author><name sortKey="Hetland, Ml" uniqKey="Hetland M">ML Hetland</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Stohl, W" uniqKey="Stohl W">W Stohl</name>
</author>
<author><name sortKey="Schwarting, A" uniqKey="Schwarting A">A Schwarting</name>
</author>
<author><name sortKey="Okada, M" uniqKey="Okada M">M Okada</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Furie, R" uniqKey="Furie R">R Furie</name>
</author>
<author><name sortKey="Khamashta, M" uniqKey="Khamashta M">M Khamashta</name>
</author>
<author><name sortKey="Merrill, Jt" uniqKey="Merrill J">JT Merrill</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Fanouriakis, A" uniqKey="Fanouriakis A">A Fanouriakis</name>
</author>
<author><name sortKey="Kostopoulou, M" uniqKey="Kostopoulou M">M Kostopoulou</name>
</author>
<author><name sortKey="Alunno, A" uniqKey="Alunno A">A Alunno</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Aringer, M" uniqKey="Aringer M">M Aringer</name>
</author>
<author><name sortKey="Strand, V" uniqKey="Strand V">V Strand</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Thanou, A" uniqKey="Thanou A">A Thanou</name>
</author>
<author><name sortKey="Merrill, Jt" uniqKey="Merrill J">JT Merrill</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Aringer, M" uniqKey="Aringer M">M Aringer</name>
</author>
<author><name sortKey="Burkhardt, H" uniqKey="Burkhardt H">H Burkhardt</name>
</author>
<author><name sortKey="Burmester, Gr" uniqKey="Burmester G">GR Burmester</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Jesus, D" uniqKey="Jesus D">D Jesus</name>
</author>
<author><name sortKey="Matos, A" uniqKey="Matos A">A Matos</name>
</author>
<author><name sortKey="Henriques, C" uniqKey="Henriques C">C Henriques</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Franklyn, K" uniqKey="Franklyn K">K Franklyn</name>
</author>
<author><name sortKey="Lau, Cs" uniqKey="Lau C">CS Lau</name>
</author>
<author><name sortKey="Navarra, Sv" uniqKey="Navarra S">SV Navarra</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Pickles, T" uniqKey="Pickles T">T Pickles</name>
</author>
<author><name sortKey="Alten, R" uniqKey="Alten R">R Alten</name>
</author>
<author><name sortKey="Boers, M" uniqKey="Boers M">M Boers</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Oliveira Santos, M" uniqKey="Oliveira Santos M">M Oliveira-Santos</name>
</author>
<author><name sortKey="Verani, Jfdes" uniqKey="Verani J">JFdeS Verani</name>
</author>
<author><name sortKey="Camacho, Lab" uniqKey="Camacho L">LAB Camacho</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Costedoat Chalumeau, N" uniqKey="Costedoat Chalumeau N">N Costedoat-Chalumeau</name>
</author>
<author><name sortKey="Pouchot, J" uniqKey="Pouchot J">J Pouchot</name>
</author>
<author><name sortKey="Guettrot Imbert, G" uniqKey="Guettrot Imbert G">G Guettrot-Imbert</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Felten, R" uniqKey="Felten R">R Felten</name>
</author>
<author><name sortKey="Dervovic, E" uniqKey="Dervovic E">E Dervovic</name>
</author>
<author><name sortKey="Chasset, F" uniqKey="Chasset F">F Chasset</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Leuchten, N" uniqKey="Leuchten N">N Leuchten</name>
</author>
<author><name sortKey="Bauernfeind, B" uniqKey="Bauernfeind B">B Bauernfeind</name>
</author>
<author><name sortKey="Kuttner, J" uniqKey="Kuttner J">J Kuttner</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Van Vollenhoven, Rf" uniqKey="Van Vollenhoven R">RF van Vollenhoven</name>
</author>
<author><name sortKey="Mosca, M" uniqKey="Mosca M">M Mosca</name>
</author>
<author><name sortKey="Bertsias, G" uniqKey="Bertsias G">G Bertsias</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Khanna, D" uniqKey="Khanna D">D Khanna</name>
</author>
<author><name sortKey="Denton, Cp" uniqKey="Denton C">CP Denton</name>
</author>
<author><name sortKey="Jahreis, A" uniqKey="Jahreis A">A Jahreis</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Khanna, D" uniqKey="Khanna D">D Khanna</name>
</author>
<author><name sortKey="Berrocal, Vj" uniqKey="Berrocal V">VJ Berrocal</name>
</author>
<author><name sortKey="Giannini, Eh" uniqKey="Giannini E">EH Giannini</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Assassi, S" uniqKey="Assassi S">S Assassi</name>
</author>
<author><name sortKey="Radstake, Trdj" uniqKey="Radstake T">TRDJ Radstake</name>
</author>
<author><name sortKey="Mayes, Md" uniqKey="Mayes M">MD Mayes</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Stifano, G" uniqKey="Stifano G">G Stifano</name>
</author>
<author><name sortKey="Sornasse, T" uniqKey="Sornasse T">T Sornasse</name>
</author>
<author><name sortKey="Rice, Lm" uniqKey="Rice L">LM Rice</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Pellar, Re" uniqKey="Pellar R">RE Pellar</name>
</author>
<author><name sortKey="Tingey, Tm" uniqKey="Tingey T">TM Tingey</name>
</author>
<author><name sortKey="Pope, Je" uniqKey="Pope J">JE Pope</name>
</author>
</analytic>
</biblStruct>
</listBibl>
</div1>
</back>
</TEI>
<affiliations><list><country><li>Allemagne</li>
<li>Autriche</li>
<li>France</li>
<li>Italie</li>
<li>Pays-Bas</li>
<li>États-Unis</li>
</country>
</list>
<tree><country name="États-Unis"><noRegion><name sortKey="Winthrop, Kevin L" sort="Winthrop, Kevin L" uniqKey="Winthrop K" first="Kevin L" last="Winthrop">Kevin L. Winthrop</name>
</noRegion>
<name sortKey="Bathon, Joan" sort="Bathon, Joan" uniqKey="Bathon J" first="Joan" last="Bathon">Joan Bathon</name>
<name sortKey="Bykerk, Vivian" sort="Bykerk, Vivian" uniqKey="Bykerk V" first="Vivian" last="Bykerk">Vivian Bykerk</name>
<name sortKey="Crofford, Leslie" sort="Crofford, Leslie" uniqKey="Crofford L" first="Leslie" last="Crofford">Leslie Crofford</name>
<name sortKey="Cronstein, Bruce N" sort="Cronstein, Bruce N" uniqKey="Cronstein B" first="Bruce N" last="Cronstein">Bruce N. Cronstein</name>
<name sortKey="Furst, Daniel" sort="Furst, Daniel" uniqKey="Furst D" first="Daniel" last="Furst">Daniel Furst</name>
<name sortKey="Furst, Daniel" sort="Furst, Daniel" uniqKey="Furst D" first="Daniel" last="Furst">Daniel Furst</name>
<name sortKey="Mease, Philip J" sort="Mease, Philip J" uniqKey="Mease P" first="Philip J" last="Mease">Philip J. Mease</name>
<name sortKey="Rosenbaum, James Todd" sort="Rosenbaum, James Todd" uniqKey="Rosenbaum J" first="James Todd" last="Rosenbaum">James Todd Rosenbaum</name>
<name sortKey="Rosenbaum, James Todd" sort="Rosenbaum, James Todd" uniqKey="Rosenbaum J" first="James Todd" last="Rosenbaum">James Todd Rosenbaum</name>
<name sortKey="Weinblatt, Michael E" sort="Weinblatt, Michael E" uniqKey="Weinblatt M" first="Michael E" last="Weinblatt">Michael E. Weinblatt</name>
</country>
<country name="Allemagne"><noRegion><name sortKey="Burmester, Gerd R" sort="Burmester, Gerd R" uniqKey="Burmester G" first="Gerd R" last="Burmester">Gerd R. Burmester</name>
</noRegion>
<name sortKey="Kalden, Joachim" sort="Kalden, Joachim" uniqKey="Kalden J" first="Joachim" last="Kalden">Joachim Kalden</name>
<name sortKey="Melchers, Fritz" sort="Melchers, Fritz" uniqKey="Melchers F" first="Fritz" last="Melchers">Fritz Melchers</name>
<name sortKey="Sieper, Joachim" sort="Sieper, Joachim" uniqKey="Sieper J" first="Joachim" last="Sieper">Joachim Sieper</name>
</country>
<country name="France"><noRegion><name sortKey="Dougados, Maxime" sort="Dougados, Maxime" uniqKey="Dougados M" first="Maxime" last="Dougados">Maxime Dougados</name>
</noRegion>
<name sortKey="Mariette, Xavier" sort="Mariette, Xavier" uniqKey="Mariette X" first="Xavier" last="Mariette">Xavier Mariette</name>
</country>
<country name="Pays-Bas"><noRegion><name sortKey="Breedveld, Ferry C" sort="Breedveld, Ferry C" uniqKey="Breedveld F" first="Ferry C" last="Breedveld">Ferry C. Breedveld</name>
</noRegion>
</country>
<country name="Autriche"><noRegion><name sortKey="Smolen, Josef S" sort="Smolen, Josef S" uniqKey="Smolen J" first="Josef S" last="Smolen">Josef S. Smolen</name>
</noRegion>
</country>
<country name="Italie"><noRegion><name sortKey="Furst, Daniel" sort="Furst, Daniel" uniqKey="Furst D" first="Daniel" last="Furst">Daniel Furst</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Sante/explor/ChloroquineV1/Data/France/Analysis

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000025 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/France/Analysis/biblio.hfd -nk 000025 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Sante
   |area=    ChloroquineV1
   |flux=    France
   |étape=   Analysis
   |type=    RBID
   |clé=     PMC:6937409
   |texte=   Unmet need in rheumatology: reports from the Targeted Therapies meeting 2019
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/France/Analysis/RBID.i   -Sk "pubmed:31662322" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/France/Analysis/biblio.hfd   \
       | NlmPubMed2Wicri -a ChloroquineV1

This area was generated with Dilib version V0.6.33.
Data generation: Wed Mar 25 22:43:59 2020. Site generation: Sun Jan 31 12:44:45 2021

Serveur d'exploration Chloroquine

Unmet need in rheumatology: reports from the Targeted Therapies meeting 2019

Unmet need in rheumatology: reports from the Targeted Therapies meeting 2019

Source :

Abstract

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Pour générer des pages wiki

	Serveur d'exploration Chloroquine
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